The Potentials of Herbal Plant against the Psoriasis

Chronic autoimmune skin disease termed psoriasis is characterised by excessive keratinocyte multiplication, scaly plaques, severe inflammation, and erythema. T lymphocytes, leukocytes, vascular endothelium, epidermal keratinocytes also contribute in the pathogenesis of psoriasis. Increased leukocyte recruitment increased levels cytokines, growth factors, genetic factors like interleukin (IL)-1, IL-6, IL-17, IL-22, IL-23, tumour necrosis factor (TNF), interferon (IFN), transforming (TGF), toll-like receptor (TLR)-2, signal transducer activator transcription (STAT-3), 15-lipoxygenase (LOX)-2. The most important aspects impacting treatment are coiled-coil alpha-helical rod protein 1 (CCHCR1), steroidogenic acute regulatory (StAR), vitamin D (VDR). Various synthetic medicinal drugs have been known to side effect Due their safety accessibility, herbal medications may indicate potential as effective anti-psoriatic agents.
 Keywords: Psoriasis, Herbal Drug, Silybum marianum, Thespesia populnea, Mahonia aquifolium